Windows 7 - Slow directory searches

I have a Windows 7 Pro machine that occasionally will have Microsoft Office programs, AutoDesk programs that will take a few seconds to jump from directory to directory and show not responding at the tops. Finally after 30 seconds or so, the directory listing will show up.

I had the latest Client SP3 IR4 installed then back rev'd hoping it was the cause but did not help. We do have file cache off in the client because we were having Microsoft Access Database issues.

We do have several other Window 7 machines but they dont experience the delays all the time like this one.

Is there another setting that needs to be changed?

Thanks in advance,
Ken